Systematic (IUPAC) name
(±)-dimethyl-1-[1-(4- chlorophenyl) cyclobutyl]-N,N,3-trimethylbutan- 1-amine
Identifiers
CAS number 106650-56-0 ATC code A08AA10 PubChem CID 5210 DrugBank APRD00456 ChemSpider 5021
Chemical data
Formula C17H26ClN Mol. mass 279.85 g/mol
Pharmacokinetic data
Bioavailability Absorption 77%, considerable first-pass metabolism Metabolism Hepatic (CYP3A4-mediated) Half-life sibutramine approx. 1 hour Metabolite 1: 14 hours Metabolite 2: 16 hours Excretion Biliary (sibutramine and active metabolites), renal (inactive metabolites)
Therapeutic considerations
Pregnancy cat. C(AU) C(US) No human data exists; inconclusive evidence of teratogenic potential in animal studies Legal status Schedule IV (US) Routes Oral